Problems in Experimental Tumorigenesis of the Pituitary Gland, Gonads, Adrenal Cortices, and Mammary Glands" A Review*

The growth of interest in endocrine aspects of oncogenesis and cancer control is reflected in reports originating from a number of recent special conferences and has led to a massive literature. A large portion of these publications is concerned with studies of experimental tumor induction in the endocrine glands and their target organs (23, 62, 67, 72, 98, 124, 129, 150, 195). Recently, interest has increased in the use of secretory tumors as endogenous sources of high hormone titers or as nomenclature will be used here (67, 71). Neoplasms tha t will grow only in specifically modified (conditioned) hosts will be spoken of as dependent. These will not grow when grafted in normal histocompatible animals but, when grafted in conditioned hosts, invade locally, can metastasize, and are eventually fatal. In contrast, tumors tha t will grow in untreated animals are termed autonomous. These often develop from dependent neoplasms of endocrine glands, may be highly secretory, and